Principles of Genetics and Biostat syllabus
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B.Sc. Sem-V : Major Core : DSC1-
T10 : Principles of Genetics (25MJ37153) Cr2 |
Hours 30 |
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Learning Objectives: The course is designed to revise basic concepts of Genetics and then
move on to advanced concepts. Some key aspects include the mechanism of
inheritance, gene structure and function, sex chromosomal and autosomal
anomalies, aspects of human genetics, etc. will be covered. A strong emphasis
will be laid on the modern tools and techniques used in genetics. |
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Unit 1 |
Basic Concepts in Genetics Concept of genes. Alleles and organization of genes in chromosome, homologous chromosomes, paternal chromosome, maternal chromosome, Autosome, Allosome, haploid, diploid, polyploid, concept of homozygous and heterozygous, concept of dominance and recessive, dominant and recessive characters in human beings, hybrid, mono hybrid ratio, dihybrid ratio. Test cross and Back cross Multiple alleles, Chromosomal mechanisms of sex determination. |
7 |
Unit 2 |
Mendelian
Laws, Allelic and genetic interaction Laws of
Mendelian Inheritance:
Contrasting characters in pea plant, Law of dominance, Law of segregation and
Law of independent assortment. Allelic
interactions: Incomplete
dominance and co-dominance. Gene
Interactions:
Supplementary, Complementary & Inhibitory interactions. Examples of
Sex-linked, sex-influenced and sex-limited characters inheritance. |
8 |
Unit 3 |
Linkage,
Crossing Over and Recombination Linkage: Characteristics of linked genes, Types of
linkage- complete and incomplete
linkage, Coupling and Repulsion. Significance of linkage. Chromosomal theory
of linkage: by T. H Morgan, Bateson and Punnett’s experiment. Recombination: Characteristics of crossing over,
Mechanisms of crossing over during meiosis, Steps involved in crossing over,
Significance of crossing over. Synaptonemal complex, Recombination
in Bacteria :
Conjugation, Transformation, Transduction |
7 |
Unit 4 |
Mutagens,
Mutations, Chromosomal aberrations and
Genetic disorders Mutagens: Physical mutagens, Chemical mutagens,
Biological mutagens. Types of gene
mutations
(Classification)- Deletion, duplication, inversion, translocation, frame
shift mutation, point mutation, substitution, missense, nonsense
mutation. Types of
chromosomal aberrations-
Numerical aberrations (Euploidy, Aneuploidy), Structural aberrations
(Deletion, Duplication, Translocation Inversion,) Genetic
Disorders: Mechanism and
characteristics of Down‘s Syndrome, Klinefelter‘s Syndrome and Turner‘s
Syndrome. Pedigree analysis of some human inherited traits |
8 |
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B.Sc.
Sem-V : Major Core : DSC1-
P8 : Practical based on
DSC1-T10 (25MJ37154) Cr 2 |
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Experiment |
Title |
1 |
Demonstration of
7 contrasting characters of pea plant. |
2 |
Examples in
Genetics based on Monohybrid ratio (03 examples) |
3 |
Examples in Genetics
based on Dihybrid ratio (03 examples) |
4 |
Example based on
Test cross (02 examples) and Back Cross (02 examples) |
5 |
Examples based on
multiple alleles: Blood groups (02 examples), Coat color in rabbit (02
examples) |
6 |
Examples based on
Complementary, Supplementary and
inhibitory gene interactions. |
7 |
Example based on
Complete linkage and Incomplete linkage in Drosophila. |
8 |
Examples based on
Coupling and Repulsion |
9 |
Examples based on
human genetic traits: Rolling tongue, free & attached ear lobes,
hitchhiker‘s thumb, PTC taste, Widows Peak Hairline (01 example from each) |
10 |
Study of Genetic
Disorders with the help of images characteristics of Down‘s Syndrome,
Klinefelter‘s Syndrome and Turner‘s Syndrome. |
11 |
Pedigree analysis
of some human inherited traits |
12 |
Calculate the
distance between two genes in map units (03 examples) |
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